Inflammation often leads to swelling, also known as edema. This usually happens in the legs and feet. The reason for this is the production of fluid that is associated with an overproduction of white blood cells. These cells and excess fluid have nowhere to go, so they tend to build up in your body and, because the fluid is so heavy, it tends to affect the legs and feet the most. So, if you experience swelling of the legs and feet ask your doctor to test you for inflammatory diseases.